SML0899

Windorphen

≥98% (HPLC)

• Synonym(s): (Z)-3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
• Empirical Formula (Hill Notation): C₁₇H₁₅ClO₃
• CAS Number: 19881-70-0
• Molecular Weight: 302.75
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-
• InChI key: VNRALGZMXHFBPG-MSUUIHNZSA-N

Description

Biochem/physiol Actions

Windorphen is a selective Wnt/β-catenin signaling inhibitor acting through selective inhibition of p300, a histone acetyltransferase (HAT) that also acts as a critical coactivator of β-catenin, a transcription factor that mediates the Wnt signaling pathway involved in embryogenesis and cancer cell survival. Windorphen blocks Wnt signaling by selectively disrupting the association of p300 with the C-terminal transactivation domain of β-catenin-1. Windorphen does not inhibit the closely related CREB-binding protein (CBP). Windorphen induced apoptosis in several Wnt-dependent tumor cell lines including colon adenocarcinoma SW480and RKO and prostate cancer cell lines DU145 and PC3.

Features and Benefits

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Other Notes

Light sensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable