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SML0312

Sigma-Aldrich

Acivicin

≥98% (HPLC)

Synonym(s):

(a-S, 5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, AT 125, Antibiotic AT 125, NSC 163501, U 42126

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About This Item

Empirical Formula (Hill Notation):
C5H7ClN2O3
CAS Number:
42228-92-2
Molecular Weight:
178.57
MDL number:
MFCD00866432
UNSPSC Code:
12352200
PubChem Substance ID:
329825317

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 10 mg/mL (warmed)

shipped in

dry ice

storage temp.

−20°C

SMILES string

N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O

InChI

1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1

InChI key

QAWIHIJWNYOLBE-OKKQSCSOSA-N

Biochem/physiol Actions

Acivicin is an antibiotic that inhibits g-glutamyl transpeptidase and transmembrane glutathione transport. Acivicin is a potent antitumor agent that induces apoptosis in human lymphoblastoid cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
062M4718V

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Christianne Bandeira-Melo et al.
The Journal of allergy and clinical immunology, 109(6), 975-979 (2002-06-14)
Eosinophils contain preformed stores of IL-4 within their cytoplasmic granules, but physiologic stimuli to release IL-4 from eosinophils are not yet defined. We evaluated whether cysteinyl leukotrienes (CysLTs) could elicit IL-4 release from eosinophils. We used a dual-antibody capture and

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