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Key Documents

SAB4501597

Sigma-Aldrich

Anti-JAK1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

JAK-1, JAK1, JAK1A, Janus kinase 1, kinase Jak1

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100 μG
$522.00

$522.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
$522.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$522.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 131 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P23458

UniProt accession no.

P23458

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JAK1(3716)

Related Categories

General description

Anti-JAK1 Antibody detects endogenous levels of total JAK1 protein.
Janus kinase 1 (JAK1) is a non-receptor tyrosine kinase, that belongs to the JAK family. It is located on human chromosome 1p31.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human JAK1.

Immunogen Range: 988-1037

Biochem/physiol Actions

Mutations in janus kinase 1 (JAK1) results in leukemia, breast cancer, lung cancer and HCC (hepatocellular carcinoma). It participates in signaling with many cytokines. JAK1 is also involved in the immune response and the initiation of allergic airway disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
217125

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JAK1 (Janus kinase 1) .
Knoops L, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis.
Shen Y, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 34(2), 124-129 (2016)
Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
Yang S et al
Oncotarget, 7(5), 5461-5469 (2016)

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