Skip to Content
MilliporeSigma
All Photos(4)

Key Documents

View All Documentation

G110

Sigma-Aldrich

Guanabenz acetate salt

powder

Synonym(s):

1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678

Sign Into View Organizational & Contract Pricing

Select a Size

25 MG
$59.58
100 MG
$135.00
500 MG
$381.60

$59.58

List Price$66.20Save 10%

In StockDetails

Request a Bulk Order
All Photos(4)

Select a Size

Change View
25 MG
$59.58
100 MG
$135.00
500 MG
$381.60

About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N4 · C2H4O2
CAS Number:
23256-50-0
Molecular Weight:
291.13
EC Number:
245-534-7
MDL number:
MFCD00153801
UNSPSC Code:
12352200
PubChem Substance ID:
24277775
NACRES:
NA.77

$59.58

List Price$66.20Save 10%

In StockDetails

Request a Bulk Order

form

powder

Quality Level

200

color

white

solubility

H2O: 10 mg/mL
alcohol: 50 mg/mL

originator

Wyeth

SMILES string

CC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

InChI key

MCSPBPXATWBACD-GAYQJXMFSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the α2-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000362746
0000362745
0000327220
0000327221
0000362745

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Pavel Tsaytler et al.
Science (New York, N.Y.), 332(6025), 91-94 (2011-03-10)
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular localization. We describe a small molecule, guanabenz, that bound to
Fabienne Gug et al.
Bioconjugate chemistry, 21(2), 279-288 (2010-01-23)
The synthesis of affinity matrices for 6-aminophenanthridine (6AP) and 2,6-dichlorobenzylidenaminoguanidine (Guanabenz, GA), two unrelated prion inhibitors, is described. In both cases, the same simple spacer, epsilon-aminocaproylaminopentanol, was introduced by a Mitsunobu reaction and the choice of the anchoring position of
Déborah Tribouillard-Tanvier et al.
PloS one, 3(4), e1981-e1981 (2008-04-24)
Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We
B Holmes et al.
Drugs, 26(3), 212-229 (1983-09-01)
Guanabenz is an orally active central alpha 2-adrenoceptor agonist. Its antihypertensive action is thought to result from a decrease in sympathetic outflow from the brain to the peripheral circulatory system as a result of stimulation of central alpha 2-adrenoceptors. In
Pavel Tsaytler et al.
The FEBS journal, 280(2), 766-770 (2012-02-22)
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. We review recent advances in the
View All Related Papers

Articles

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service