E114

EHNA hydrochloride

≥98% (HPLC), powder, adenosine deaminase inhibitor

• Synonym(s): erythro-9-(2-Hydroxy-3-nonyl)­adenine hydrochloride, erythro-9-Amino-β-hexyl-­α-methyl-9H-purine-9-ethanol hydrochloride
• Empirical Formula (Hill Notation): C₁₄H₂₃N₅O · HCl
• CAS Number: 58337-38-5
• Molecular Weight: 313.83
• MDL number: MFCD00151066
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277713
• NACRES: NA.77

Properties

• product name: EHNA hydrochloride, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• storage condition: desiccated
• solubility: DMSO: >10 mg/mL; H₂O: >10 mg/mL
• SMILES string: Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
• InChI: 1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
• InChI key: VVDXNJRUNJMYOZ-VZXYPILPSA-N
• Gene Information: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Description

General description

EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.

Application

EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.

Biochem/physiol Actions

Adenosine deaminase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)