This material is quite soluble in water. The rate of solubility in water has not been established. However, other sources report rates up to 560 mg/mL. Solutions prepared in water are stable when refrigerated at 2-8 °C for at least 60 days. Avoid storing solutions prepared in isotonic buffers, as the literature indicates a possible increase in the rate of decomposition.
C4461
Colistin sulfate salt
≥19,000 IU/mg
Synonym(s):
Polymyxin E
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100 MG
$56.80
1 G
$261.00
About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
51102829
eCl@ss:
34050906
NACRES:
NA.85
Recommended Products
form
powder
Quality Level
specific activity
≥19,000 IU/mg
antibiotic activity spectrum
Gram-negative bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)O.N1[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)CCN)CCN)CC(C)C)CC(C)C)CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC(CC)C)CCN)[C@H](O)C)CCN)[C@H](O)C
InChI
1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
InChI key
ZJIWRHLZXQPFAD-LRYSGCCDSA-N
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General description
Chemical structure: peptide
Application
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii [1]. It has been used to study hephrotoxicity in the rat kidney [2], and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa [3].
Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH [2].
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH [2].
Analysis Note
Freely soluble in water, practically insoluble in acetone and in ethanol (96%)
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
related product
Product No.
Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Customers Also Viewed
Peng Cui et al.
Antimicrobial agents and chemotherapy, 60(11), 6867-6871 (2016-09-08)
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
Deepesh Nagarajan et al.
Science advances, 5(7), eaax1946-eaax1946 (2019-07-30)
Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
Ansley M Nemeth et al.
ChemMedChem, 15(2), 210-218 (2019-11-23)
Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-negative bacteria, are an escalating global health threat. Often clinicians are forced to administer the last-resort antibiotic colistin; however, colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation
Mehri Haeili et al.
Microbial drug resistance (Larchmont, N.Y.), 24(9), 1271-1276 (2018-03-29)
Colistin is considered a last-hope antibiotic against extensively drug-resistant isolates of Acinetobacter baumannii. Resistance to colistin has been rarely reported for A. baumannii. Genetic alterations in the PmrA-PmrB two-component system and lipid A biosynthesis genes may be associated with colistin
Anna Ebbensgaard et al.
Frontiers in microbiology, 9, 2153-2153 (2018-09-25)
Bacterial resistance to classical antibiotics is emerging worldwide. The number of infections caused by multidrug resistant bacteria is increasing and becoming a serious threat for human health globally. In particular, Gram-negative pathogens including multidrug resistant Escherichia coli are of serious
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1. What is the solubility of this antibiotic in water? How many mg of the substance can dissolve in 1 mL of water? 2. After preparing a diluted solution of the antibiotic in water, where should it be stored, and what is the recommended storage duration?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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what is potency in microgram/mg?
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As per the International Standard Preparation (1968), for comparative purposes, each microgram (ug) of colistin base is equivalent to 30 units. As an example, a lot reporting an activity of 22,891 units/mg would have the equivalent of 763 ug of colistin base per mg solid. This product has a minimum activity specification of 19,000 IU/mg, which equates to 633 ug colistin base per mg solid. The activity is reported on a lot specific basis on the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate.
https://www.sigmaaldrich.com/product/sigma/c4461#product-documentationHelpful?
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What is the recommended storage temperature for the powder after opening the bottle and weighing 10 mg?
1 answer-
The product should be stored at 2-8°C both before and after it is opened.
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May you please indicate if this product is from a biological source or if it is synthesized? Many thanks
1 answer-
Currently, this product is produced from an animal component free microbial fermentation process. A lot specific Certificate of Origin can be supplied by our Technical Service team who can assist you with further. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Documentation" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
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What is the molecular weight?
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The average molecular weight is 1155.4 g/mol.
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After opening the bottle and weigh 10 mg of powder what about storage of powder after opening in refrigerator or no ?
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This product should be stored in 2-8°C before and after opening.
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