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V6505

Sigma-Aldrich

Valosin Porcine

≥97% (HPLC)

Synonym(s):

Peptide VQY, Val-Gln-Tyr-Pro-Val-Glu-His-Pro-Asp-Lys-Phe-Leu-Lys-Phe-Gly-Met-Thr-Pro-Ser-Lys-Gly-Val-Leu-Phe-Tyr

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About This Item

Empirical Formula (Hill Notation):
C141H207N31O35S
CAS Number:
99510-37-9
Molecular Weight:
2928.40
MDL number:
MFCD00133919
UNSPSC Code:
12352202
PubChem Substance ID:
24900761
NACRES:
NA.26

assay

≥97% (HPLC)

UniProt accession no.

P03974

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(CC(O)=O)NC(=O)C3CCCN3C(=O)C(Cc4cnc[nH]4)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C5CCCN5C(=O)C(Cc6ccc(O)cc6)NC(=O)C(CCC(N)=O)NC(=O)C(N)C(C)C)C(C)C)C(=O)NC(C(C)O)C(=O)N7CCCC7C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(Cc8ccccc8)C(=O)NC(Cc9ccc(O)cc9)C(O)=O

InChI

1S/C141H207N31O35S/c1-77(2)63-97(157-128(193)100(66-84-33-18-14-19-34-84)159-122(187)93(39-24-27-58-144)154-130(195)102(71-114(182)183)161-132(197)107-40-28-59-170(107)139(204)104(70-88-72-147-76-150-88)164-124(189)95(52-54-113(180)181)156-137(202)117(81(9)10)168-134(199)109-42-29-60-171(109)138(203)103(68-86-43-47-89(175)48-44-86)163-123(188)94(51-53-110(145)177)155-135(200)115(146)79(5)6)126(191)153-92(38-23-26-57-143)121(186)158-99(65-83-31-16-13-17-32-83)120(185)149-73-111(178)151-96(55-62-208-12)125(190)169-118(82(11)174)140(205)172-61-30-41-108(172)133(198)166-106(75-173)131(196)152-91(37-22-25-56-142)119(184)148-74-112(179)167-116(80(7)8)136(201)162-98(64-78(3)4)127(192)160-101(67-85-35-20-15-21-36-85)129(194)165-105(141(206)207)69-87-45-49-90(176)50-46-87/h13-21,31-36,43-50,72,76-82,91-109,115-118,173-176H,22-30,37-42,51-71,73-75,142-144,146H2,1-12H3,(H2,145,177)(H,147,150)(H,148,184)(H,149,185)(H,151,178)(H,152,196)(H,153,191)(H,154,195)(H,155,200)(H,156,202)(H,157,193)(H,158,186)(H,159,187)(H,160,192)(H,161,197)(H,162,201)(H,163,188)(H,164,189)(H,165,194)(H,166,198)(H,167,179)(H,168,199)(H,169,190)(H,180,181)(H,182,183)(H,206,207)

InChI key

OVSVDLZVCMFSDM-UHFFFAOYSA-N

Gene Information

pig ... VCP(397524)

Biochem/physiol Actions

Stimulates pancreatic secretion.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
119H1420
119H14201
016H1590
016H15901
057F06681

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Valosin stimulates gastric and exocrine pancreatic secretion and inhibits fasting small intestinal myoelectric activity in the dog.
Konturek SJ, Schmidt WE, et al.
Gastroenterologie Clinique Et Biologique, 92, 1181-1186 (1987)
W E Schmidt et al.
FEBS letters, 191(2), 264-268 (1985-10-28)
The isolation and primary structure of a novel gastrointestinal peptide, designated valosin, is described. The peptide was purified from porcine upper gut extracts using an HPLC and N-terminal sequence screening strategy which depends on chromatographic and structural characteristics as isolation
Petra Hänzelmann et al.
The Journal of biological chemistry, 286(44), 38679-38690 (2011-09-15)
The AAA (ATPase associated with various cellular activities) ATPase p97, also referred to as valosin-containing protein (VCP), mediates essential cellular processes, including ubiquitin-dependent protein degradation, and has been linked to several human proteinopathies. p97 interacts with multiple cofactors via its

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