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U5760

Sigma-Aldrich

(4R)-2-Undecyl-4-thiazolidinecarboxylic acid

≥98% (HPLC)

Synonym(s):

2-Undecylthiazolidine-4(R)-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C15H29NO2S
CAS Number:
Molecular Weight:
287.46
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCC1N[C@@H](CS1)C(O)=O

InChI

1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18)/t13-,14?/m0/s1

InChI key

FNBSOIBCKUUVJJ-LSLKUGRBSA-N

Biochem/physiol Actions

BML-241 is a S1P3 (shingosine-1-phosphate receptor) specific antagonist. Treatment with 10 uM BML-241 results in a 40% inhibition of Ca influx in HeLa cells.
BML-241 is a S1P3 receptor antagonist.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

(4R)-2-Undecyl-4-thiazolidinecarboxylic acid is soluble in DMSO at a concentration that is >5 mg/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Bruno Jaime Santacreu et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(4), 158888-158888 (2021-01-18)
Collecting duct cells are physiologically subject to the hypertonic environment of the kidney. This condition is necessary for kidney maturation and function but represents a stress condition that requires active strategies to ensure epithelial integrity. Madin-Darby Canine Kidney (MDCK) cells

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