U4760

UR-AK57 dihydrochloride

≥98% (HPLC)

• Synonym(s): N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)-propyl]guanidine dihydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₉N₅O·2HCl
• CAS Number: 902154-35-2
• Molecular Weight: 392.37
• MDL number: MFCD17215973
• UNSPSC Code: 12352200
• PubChem Substance ID: 329827632
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CC(CC(=O)NC(=N)NCCCc1ncc[nH]1)C2CCCCC2
• InChI: 1S/C17H29N5O.2ClH/c1-13(14-6-3-2-4-7-14)12-16(23)22-17(18)21-9-5-8-15-19-10-11-20-15;;/h10-11,13-14H,2-9,12H2,1H3,(H,19,20)(H3,18,21,22,23);2*1H
• InChI key: IBBYQLOGMIDRMM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine.

Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine. Histamine receptors are GPCRS and have long been therapeutic targets for allergic rhinitis. In brain, histamine receptors are targets for psychotherapeutics.

UR-AK57 is known to function as an effective, partial histamine H₁-receptor (H₁R) and H₂-receptor (H₂R) agonist[1].

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UR-AK57 dihydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable