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U4625

Sigma-Aldrich

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae

≥98%

Synonym(s):

UDP-Glc hydrate, UDPG hydrate

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10 MG
$33.74
25 MG
$40.32
100 MG
$102.90
500 MG
$396.00
1 G
$573.00
5 G
$1,826.19

$33.74

List Price$36.40Save 7%

Available to ship onApril 01, 2025Details

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10 MG
$33.74
25 MG
$40.32
100 MG
$102.90
500 MG
$396.00
1 G
$573.00
5 G
$1,826.19

About This Item

Empirical Formula (Hill Notation):
C15H22N2Na2O17P2 · xH2O
CAS Number:
28053-08-9
Molecular Weight:
610.27 (anhydrous basis)
MDL number:
MFCD20441966
UNSPSC Code:
41106305
PubChem Substance ID:
24900648
NACRES:
NA.51

$33.74

List Price$36.40Save 7%

Available to ship onApril 01, 2025Details

biological source

Saccharomyces cerevisiae

assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].OC[C@H]1O[C@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C15H24N2O17P2.2Na.H2O/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;;1H2/q;2*+1;/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;;/m1.../s1

InChI key

SRHFBUUOPANXBG-WSIJJEQHSA-L

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General description

Uridine diphosphate glucose (UDP-glucose) is a glycogen precursor. The transfer of glucose from UDP-glucose to growing glycogen chain is catalyzed by the enzyme glycogen synthase. The enzyme uridine diphosphate galactose-4-epimerase catalyzes the formation of UDP-glucose from UDP-galactose.[1]

Application

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae has been used as a substrate
  • for the PpIRX10 enzyme activity from Arabidopsis thaliana[2]
  • in radiometric assay of glycosyltransferases (GTs)[3]
  • in uridine diphosphate glucose (UDP-Glc) 4-epimerase assay in Arabidopsis thaliana samples[4]

Biochem/physiol Actions

Uridine diphosphate glucose (UDP-glucose) is an essential mediator of the cellular metabolic pathways.[5] In yeast, the high levels of trehalose and glycogen favor increased levels of UDP-glucose.[6]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000429082
0000429082
0000421591
0000421591
0000421393

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Hypoglycemia as a Pathological Result in Medical Praxis
Type 1 Diabetes Complications (2011)
Distinct properties of the five UDP-D-glucose/UDP-D-galactose 4-epimerase isoforms of Arabidopsis thaliana
Barber C, et al.
The Journal of Biological Chemistry, 281(25), 17276-17285 (2006)
Fariborz Parandeh et al.
The Journal of biological chemistry, 295(45), 15245-15252 (2020-08-29)
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative
A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism
Fuhring J, et al.
Scientific Reports, 5, 9618-9618 (2015)
Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis
Hong KK, et al.
Proceedings of the National Academy of Sciences of the USA, 108(29), 12179-12184 (2011)
View All Related Papers

Articles

Glycosyltransferases: Tools for Synthesis and Modification of Glycans

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Glycosyltransferases

Enzymatic glycosyltransferase specificity challenges the one enzyme-one linkage concept.

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