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T9177

Sigma-Aldrich

Tyrphostin AG 126

≥90%

Synonym(s):

(3-Hydroxy-4-nitrobenzylidene)malononitrile

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About This Item

Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
118409-62-4
Molecular Weight:
215.17
MDL number:
MFCD00236448
UNSPSC Code:
12352200
PubChem Substance ID:
24278763

assay

≥90%

storage temp.

−20°C

SMILES string

Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N

Gene Information

human ... TNF(7124)

Application

Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.

Biochem/physiol Actions

Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Oliver Kann et al.
Journal of neurochemistry, 90(3), 513-525 (2004-07-17)
We recently reported that lasting activation of mouse microglial cells with bacterial lipopolysaccharide (LPS) chronically elevated the basal intracellular calcium concentration ([Ca2+]i). This correlated to an attenuated calcium signaling of complement (C5a) and purinergic (UTP) receptors as well as to
Hua Yuan et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H470-H479 (2008-12-23)
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial depression that is a common feature of endotoxemia in patients. In this setting the myocardial dysfunction appears to be due
M G Rittig et al.
Cellular microbiology, 5(12), 887-899 (2003-12-04)
Following reports that a VacA+cag+ toxigenic but not a VacA-cag- non-toxigenic Helicobacter pylori strain induced homotypic phagosome fusion in murine macrophages, we addressed that phenomenon in human cells. Mononuclear phagocytes and epitheloid cells were challenged with H. pylori strains of
Klemens Angstwurm et al.
Infection and immunity, 72(6), 3294-3298 (2004-05-25)
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components contributes to this devastating outcome. In vitro studies have
Beverley A Moore et al.
American journal of physiology. Gastrointestinal and liver physiology, 286(2), G214-G224 (2003-09-27)
Manipulation of the bowel during abdominal surgery leads to a period of ileus, which is most severely manifested after procedures that directly involve the colon. Ileus is associated with the increased expression of proinflammatory cytokines and chemokines, a leukocytic infiltration
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