T8806

Thymopentin

≥97% (HPLC)

• Synonym(s): TP5, Arg-Lys-Asp-Val-Tyr
• Empirical Formula (Hill Notation): C₃₀H₄₉N₉O₉
• CAS Number: 69558-55-0
• Molecular Weight: 679.76
• MDL number: MFCD00214200
• UNSPSC Code: 12352209
• PubChem Substance ID: 329826886
• NACRES: NA.26

Properties

• Product Name: Thymopentin, ≥97% (HPLC)
• Quality Level: 200
• assay: ≥97% (HPLC)
• form: powder
• color: white
• application(s): cell analysis
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
• InChI: 1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1
• InChI key: PSWFFKRAVBDQEG-YGQNSOCVSA-N

Description

Amino Acid Sequence

Arg-Lys-Asp-Val-Tyr

General description

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).[1]

Biochem/physiol Actions

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation,[1] natural killer (NK) cell and macrophage activation,[2] generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus.[1] TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.[3]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)