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T2825

TIQ-A

Name: TIQ-A
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

Thieno[2,3-c]isoquinolin-5-one

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₇NOS

CAS Number:

420849-22-5

Molecular Weight:

201.24

MDL number:

MFCD06407947

UNSPSC Code:

12352200

PubChem Substance ID:

24724630

NACRES:

NA.77

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 16 mg/mL

storage temp.

2-8°C

SMILES string

O=C1Nc2sccc2-c3ccccc13

InChI

1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)

InChI key

LQJVOLSLAFIXSV-UHFFFAOYSA-N

Application

TIQ-A has been used as a PAPR-1 inhibitor to study eosinophilic infiltration into the airways of OVA-challenged mice¹. It has also been used to study its role in the regression of atherosclerotic plaques in high-fat diet-fed ApoE(-/-) mice².

Biochem/physiol Actions

TIQ-A is a potent inhibitor of PARP, anti-apoptotic.

Preparation Note

TIQ-A is soluble in DMSO at 16 mg/ml.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.

Chetan P Hans et al.

The Journal of pharmacology and experimental therapeutics, 329(1), 150-158 (2009-01-07)

We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression in heterozygous animals interferes with atherogenesis and may promote factors of plaque stability, possibly reflecting

Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5.

Mustapha Oumouna et al.

Journal of immunology (Baltimore, Md. : 1950), 177(9), 6489-6496 (2006-10-24)

We recently used a murine model of allergic airway inflammation to show that poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the pathogenesis of asthma-related lung inflammation. In this study, we show that PARP-1 inhibition, by a novel inhibitor (TIQ-A)

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