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Key Documents

SML0145

Sigma-Aldrich

MRT-10

≥98% (HPLC)

Synonym(s):

N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide

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About This Item

Empirical Formula (Hill Notation):
C24H23N3O5S
CAS Number:
Molecular Weight:
465.52
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc2cccc(NC(=O)c3ccccc3)c2

InChI

1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33)

InChI key

KVQVEZQDNHMQJV-UHFFFAOYSA-N

Biochem/physiol Actions

MRT-10 is a novel, high-affinity antagonist of smoothened (Smo). MRT-10 displaces labeled cyclopamine from Smo with an IC50 of 500 nM, and inhibits shh-induced Gli-reporter activity in Shh-light2 cells (IC50 = 0.64 μM).
MRT-10 is a smoothened antagonist

pictograms

CorrosionEnvironment

signalword

Danger

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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