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S8385

Sigma-Aldrich

[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11

≥95% (HPLC)

Synonym(s):

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C43H61N9O9S
CAS Number:
77128-69-9
Molecular Weight:
880.06
MDL number:
MFCD00133835
UNSPSC Code:
12352200
PubChem Substance ID:
329824602

assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O

InChI

1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)

InChI key

IEEBRBMEXFNVKU-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

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Biochem/physiol Actions

Substance P analog which is resistant to attack by a substance P degrading enzyme.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J M Barnes et al.
Pharmacology, biochemistry, and behavior, 37(4), 839-841 (1990-12-01)
The effect on forebrain catecholamine- and indoleamine-related neurochemical levels was investigated following stimulation of the rat ventral tegmental area with the substance P analogue, DiMe-C7. DiMe-C7 (6.0 micrograms) induced a marked hyperactivity in rats with maximal response between 15 and
J Mao et al.
Brain research, 574(1-2), 157-163 (1992-03-06)
The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching induced by i.t. substance P (SP), bombesin (BBS), strychnine (STR), and kainic acid (KA). CGRP alone (5.25, 10.5 and
N Altier et al.
Behavioural brain research, 89(1-2), 151-165 (1998-02-25)
Experiments were designed to examine the analgesic effects induced by selective tachykinin receptor agonists microinfused into either the ventral tegmental area (VTA) or nucleus accumbens septi (NAS). Rats were tested in the formalin test for tonic pain following an injection
J L Cornish et al.
Neuroscience letters, 176(2), 142-146 (1994-08-01)
Central dopaminergic systems have been implicated in the regulation of blood pressure. We examined the effect on blood pressure of electrical or chemical stimulation of the rat brain ventral tegmental area (VTA) which is the region of origin of the
R Mathison et al.
Brain research, 644(2), 251-256 (1994-05-02)
The effects of intravenous injection of prostaglandin E2 (PGE2), substance P (SP) and a metabolically stable SP analogue, [pGlu5,Me-Phe8,Sar9]-SP (5-11) on plasma extravasation of albumin in the rat after blockade of prostaglandin synthesis with indomethacin or chemical sympathectomy with guanethidine
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