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S7029

Sigma-Aldrich

[Pro9]-Substance P

≥97% (HPLC)

Synonym(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C66H102N18O13S
CAS Number:
104486-69-3
Molecular Weight:
1387.69
MDL number:
MFCD00214104
UNSPSC Code:
12352200
PubChem Substance ID:
24899730

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccccc3)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(N)=O

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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J C Delumeau et al.
Journal of neurochemistry, 57(6), 2026-2035 (1991-12-01)
The effects on cytosolic Ca2+ concentration of 2-chloroadenosine and [L-Pro9]-substance P, a selective agonist of NK1 receptors, were investigated on astrocytes from embryonic mice in primary culture. Cells responded to [L-Pro9]-substance P with a transitory increase in cytosolic Ca2+ which
Y Torrens et al.
Neuropeptides, 31(3), 243-251 (1997-06-01)
The rat urinary bladder possesses NK1, NK2 (but not NK3) and 'septide-sensitive' tachykinin receptors coupled to a phospholipase C. The present study performed with SR48968 (10(-6) M) to avoid any interaction of the tested peptides with NK2 receptors, indicates that
S Lavielle et al.
European journal of pharmacology, 258(3), 273-276 (1994-06-13)
In the guinea-pig ileum tissue, [Pro9]substance P, a tachykinin NK1 receptor selective agonist and septide, [pGlu6,Pro9]-substance P-(6-11), do not interact with the same receptor as shown by the different inhibitory profiles of GR 72251 and [D-Pro9,Pro10,Trp11]substance P. Substitution at position
C Gauchy et al.
Neuroscience, 73(4), 929-939 (1996-08-01)
The effects of septide (a short substance P C-terminal analogue) and of the neurokinin-1 receptor agonist [Pro9]substance P on the N-methyl-D-aspartate (50 microM)-evoked release of [3H]dopamine (continuously synthesized from [3H]tyrosine) were investigated in the absence or the presence of the
F Petitet et al.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 314(7), 299-303 (1992-03-26)
[Pro9]SP and septide have been described as selective agonists for the SP receptor (NK-1 type). These two peptides contract with a great efficacy the guinea-pig ileum, but unexpectedly septide was practically devoid of affinity for the NK-1 site labelled by
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