S6764
[pGlu6, Pro9]-Substance P fragment 6-11
≥95% (HPLC)
Synonym(s):
Septide, pGlu-Phe-Phe-Pro-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C39H53N7O7S
CAS Number:
Molecular Weight:
763.95
MDL number:
UNSPSC Code:
12352200
assay
≥95% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
A potent and selective NK-1 tachykinin receptor agonist.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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P J Johnson et al.
British journal of pharmacology, 124(7), 1375-1384 (1998-09-02)
1. The role of NK1 and NK3 receptors in synaptic transmission between myenteric neurons during motility reflexes in the guinea-pig ileum was investigated by recording intracellularly the reflex responses of the circular muscle to distension or compression of the mucosal
M J Bourque et al.
The Journal of physiology, 512 ( Pt 1), 197-209 (1998-09-08)
1. Although peptides are important modulators of synapses, their action on synapse-glia interactions remain unclear. The amphibian neuromuscular junction (NMJ) was used to examine the effects of substance P (SP) on perisynaptic Schwann cells (PSCs), glial cells at the frog
A Wijkhuisen et al.
FEBS letters, 447(2-3), 155-159 (1999-04-24)
The three mammalian tachykinins, substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), exert their physiological effects through specific receptors, NK1, NK2 and NK3, respectively. However, homologous binding studies have recently demonstrated that, contrary to the generally accepted belief
S B Mazzone et al.
British journal of pharmacology, 129(6), 1121-1131 (2000-03-22)
1. The respiratory response to microinjection of tachykinins and analogues into the commissural nucleus of the solitary tract (cNTS) of urethane-anaesthetized rats was investigated in the presence and absence of selective tachykinin NK(1), NK(2) and NK(3) antagonists (RP 67580, SR
J C Beaujouan et al.
Journal of neurochemistry, 75(3), 1015-1026 (2000-08-11)
(2-[(125)I]iodohistidyl(1))Neurokinin A ([(125)I]NKA), which labels "septide-sensitive" but not classic NK(1) binding sites in peripheral tissues, was used to determine whether septide-sensitive binding sites are also present in the rat brain. Binding studies were performed in the presence of SR 48968
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