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S6321

Suptopin-2

Name: Suptopin-2
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-Hydroxy-3-[3-(4-hydroxy-3,5-dimethyoxyphenyl)-1-oxo-2-propenyl]-6-methyl-2H-pyran-2-one, Suppressor of Topoisomerase II Inhibition

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₆O₇

CAS Number:

331852-66-5

Molecular Weight:

332.30

MDL number:

MFCD00810236

UNSPSC Code:

12352202

PubChem Substance ID:

24724619

NACRES:

NA.77

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assay

≥98% (HPLC)

form

solid

solubility

DMSO: 11 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(\C=C\C(=O)C2=C(O)C=C(C)OC2=O)cc(OC)c1O

InChI

1S/C17H16O7/c1-9-6-12(19)15(17(21)24-9)11(18)5-4-10-7-13(22-2)16(20)14(8-10)23-3/h4-8,19-20H,1-3H3/b5-4+

InChI key

NCXJIWTVFHYSKF-SNAWJCMRSA-N

Application

Suptopin-2 may be used to study cell signaling leading to cell cycle arrest.

Biochem/physiol Actions

Suptopin-2 affects cell cycle progression and stability of microtubules. It induces cell cycle arrest by regulating the nucleocytoplasmic transport of cyclin B1.¹

Sutopin-2 is a suppressor of topoisomerase II inhibition. Reverses cell cycle arrest; bypass of checkpoint function. Has inherent fluorescence and a distinct advantage in identification of molecule targets; effective concentraion in the μM range.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

036K4610

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Small molecule modulation of the human chromatid decatenation checkpoint.

Stephen J Haggarty et al.

Chemistry & biology, 10(12), 1267-1279 (2004-01-01)

After chromosome replication, the intertwined sister chromatids are disentangled by topoisomerases. The integrity of this process is monitored by the chromatid decatenation checkpoint. Here, we describe small molecule modulators of the human chromatid decatenation checkpoint identified using a cell-based, chemical

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