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S5521

Sigma-Aldrich

Suxibuzone

Synonym(s):

4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)

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About This Item

Empirical Formula (Hill Notation):
C24H26N2O6
CAS Number:
27470-51-5
Molecular Weight:
438.47
EC Number:
248-477-6
MDL number:
MFCD00079562
UNSPSC Code:
12352202
PubChem Substance ID:
24899658

form

solid

SMILES string

CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

InChI

1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)

InChI key

ONWXNHPOAGOMTG-UHFFFAOYSA-N

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Biochem/physiol Actions

A prodrug of phenylbutazone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
089F0243

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[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione (suxibuzone), antiinflammatory drug. II. The biological fate of suxibuzone (SB) after daily oral administration (author's transl)].
K Taira et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 100(3), 272-279 (1980-03-01)
S Yanagi et al.
Cancer letters, 36(1), 11-18 (1987-07-01)
Among phenylbutazone (PZ) and its related compounds, suxibuzone (SUX) caused the most extensive decrease in pyruvate kinase (PK) activity with lower toxicity. Therefore, we studied the effect of SUX on rat hepatocarcinogenesis to confirm our assumption that an agent which
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione(suxibuzone), antiinflammatory drug. I. Plasma levels and urinary excretion after oral administration of suxibuzone (author's transl)].
T Shindo et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 99(12), 1186-1200 (1979-12-01)
L Monreal et al.
Research in veterinary science, 76(2), 145-149 (2003-12-16)
The objective was to compare the gastrointestinal and general toxicity of suxibuzone (SBZ) to that of phenylbutazone (PBZ) when administered orally in horses. Fifteen healthy horses were allocated to three treatment groups. One group received a high dose of PBZ
Pro-drugs of non-steroidal anti-inflammatory agents.
Y Mizushima
European journal of rheumatology and inflammation, 6(2), 141-142 (1983-01-01)
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