S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

• Synonym(s): α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
• Empirical Formula (Hill Notation): C₁₆H₁₂F₃N₃S
• CAS Number: 305350-87-2
• Molecular Weight: 335.35
• MDL number: MFCD06411432
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824537
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated; protect from light
• color: white to off-white
• mp: 127-128.2 °C
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
• InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• InChI key: JLOXTZFYJNCPIS-FYWRMAATSA-N

Description

Application

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)