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S3922

Sigma-Aldrich

[Methyl-D-Phe6, D-Trp7,9, Leu10-psi(CH2NH)Leu11]-Substance P Fragment 6-11

≥97% (HPLC)

Synonym(s):

Methyl-D-Phe-D-Trp-Phe-D-Trp-Leu-psi[CH2NH]-Leu-NH2

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About This Item

Empirical Formula (Hill Notation):
C53H67N9O5
CAS Number:
152369-60-3
Molecular Weight:
910.16
MDL number:
MFCD00792897
UNSPSC Code:
12352200

assay

≥97% (HPLC)

composition

Peptide content, ~70%

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CN[C@H](Cc1ccccc1)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]c6ccccc56)C(=O)N[C@H](CN[C@@H](CC(C)C)C(N)=O)CC(C)C

Gene Information

human ... TAC1(6863)

Biochem/physiol Actions

This substance P analog inhibited small-cell lung cancer proliferation in vitro and in vivo.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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A Orosz et al.
International journal of cancer, 60(1), 82-87 (1995-01-03)
Human small-cell lung-cancer cells (SCLC) produce and secrete gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin (BN). There is some evidence to suggest that GRP is an autocrine regulator of SCLC cell growth. In the search for potent BN antagonists

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