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S174

Sigma-Aldrich

SDZ-205,557 hydrochloride

solid

Synonym(s):

4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H21ClN2O3 · HCl
CAS Number:
137196-67-9
Molecular Weight:
337.24
MDL number:
MFCD00671790
UNSPSC Code:
12352200
PubChem Substance ID:
24278128
NACRES:
NA.77

form

solid

color

off-white

solubility

DMSO: 100 mg/mL
H2O: 65 mg/mL
ethanol: insoluble

originator

Sandoz

SMILES string

Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC

InChI

1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H

InChI key

JOWUQCJWCRNVMQ-UHFFFAOYSA-N

Gene Information

human ... HTR4(3360)

Biochem/physiol Actions

Potent, selective 5-HT4 serotonin receptor antagonist.

Features and Benefits

This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E F Espejo et al.
Brain research, 788(1-2), 20-24 (1998-05-21)
The role of 5-HT4 receptors on cutaneous and visceral pain remains largely unexplored. The objective of this study was to establish the activity profile of SDZ 205-557, a 5-HT4 antagonist, on cutaneous (hotplate) and visceral (writhing) models of pain, after
Y Nagakura et al.
Naunyn-Schmiedeberg's archives of pharmacology, 353(5), 489-498 (1996-04-01)
We examined the effects of exogenous 5-hydroxytryptamine (5-HT) and selective 5-HT receptor agonists and antagonists on proximal, middle and distal colonic motility in conscious fasted dogs with extraluminal force transducers implanted chronically. 5-HT (0.003-0.1 mg/kg i.v.) dose-dependently enhanced motility along
J F Kuemmerle et al.
Gastroenterology, 109(6), 1791-1800 (1995-12-01)
The type and function of 5-hydroxytryptamine (5HT) receptors on intestinal muscle cells in humans are not known. 5-HT receptors were characterized pharmacologically and by radioligand binding. Contraction, relaxation, inositol 1,4,5-triphosphate (IP3) and adenosine 3',5'-cyclic monophosphate (cAMP) formation, and 5-HT binding
K H Buchheit et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(4), 387-393 (1992-04-01)
A selective antagonist for the recently characterized 5-HT4 receptor is lacking. The only surmountable antagonist available, ICS 205-930, is a weak antagonist and is far more potent at 5-HT3-than at 5-HT4 receptors. In this paper, SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino)
K H Buchheit et al.
European journal of pharmacology, 262(1-2), 91-97 (1994-09-01)
5-Hydroxytryptamine (5-HT) contracts and relaxes isolated stomach preparations. This study attempts to characterise receptors involved in the contractile response using electrically stimulated circular muscle strips from guinea pig stomach. Electrically induced contractions were abolished by atropine and tetrodotoxin. 5-HT enhanced
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