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S110

Sigma-Aldrich

(±)-SKF-83566 hydrochloride

solid

Synonym(s):

(±)-7-Bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, (±)-SCH-24543

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About This Item

Empirical Formula (Hill Notation):
C17H18BrNO · HCl
CAS Number:
99295-33-7
Molecular Weight:
368.70
MDL number:
MFCD00055230
UNSPSC Code:
12352200

form

solid

storage condition

protect from light

color

light tan

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: ≥14 mg/mL
0.1 M HCl: soluble
H2O: insoluble
ethanol: soluble

SMILES string

Cl.CN1CCc2cc(Br)c(O)cc2C(C1)c3ccccc3

Biochem/physiol Actions

Selective D1 dopamine antagonist; useful in studies involving the radio-brominated derivative.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
048H46943

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Synthesis of a radiobrominated analog of SCH-23390, a selective dopamine D1/DA1 antagonist.
DeJesus, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 23, 919-919 (1986)
J Arnt et al.
Journal of neural transmission, 67(3-4), 225-240 (1986-01-01)
The effects of 30 dopamine (DA) antagonists, including 4 as stereoisomeric pairs, on circling behaviour induced by the D-1 agonist SKF 38393 and the D-2 agonist pergolide in rats with unilateral 6-hydroxy-DA lesions have been studied. SKF 38393-induced circling was
K E Flaim et al.
Life sciences, 36(15), 1427-1436 (1985-04-15)
Fenoldopam (SKF 82526), a dopamine agonist which exhibits D-1 receptor subtype selectivity, was evaluated as a radioligand for this receptor subtype. In saturation studies in rat striatal membrane preparations, [3H]-fenoldopam appeared to label a single binding site with a KD

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