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S103

Sigma-Aldrich

Spiroxatrine

powder

Synonym(s):

(±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one, R 5188

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About This Item

Empirical Formula (Hill Notation):
C22H25N3O3
CAS Number:
1054-88-2
Molecular Weight:
379.45
MDL number:
MFCD00055134
UNSPSC Code:
12352200
PubChem Substance ID:
24278126

form

powder

color

white

solubility

0.1 M HCl: moderately soluble
DMSO: soluble
H2O: slightly soluble

SMILES string

O=C1NCN(c2ccccc2)C13CCN(CC3)CC4COc5ccccc5O4

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

Partial 5-HT1A serotonin receptor agonist and α adrenoceptor antagonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J A Terrón et al.
Journal of autonomic pharmacology, 14(3), 165-175 (1994-06-01)
1. The present study was designed to analyse the effect of the centrally-acting sympatho-inhibitory drugs, prazosin and ketanserin, on the increase in external carotid blood flow (external CBF) produced by 5-hydroxytryptamine (5-HT) in pentobarbital-anaesthetized dogs. 2. Intracarotid (i.c.) infusions of
Yong Hyeon Baek et al.
Brain research, 1057(1-2), 181-185 (2005-09-06)
The analgesic effect and its mechanism of electroacupuncture (EA) on inflammatory pain, especially in the rat model of collagen-induced arthritis (CIA), have not yet been studied. This study was designed to investigate the analgesic effect and its cholinergic and serotonergic
J A Terrón et al.
Archivos del Instituto de Cardiologia de Mexico, 63(4), 289-295 (1993-07-01)
The 5-HT1A ligand, spiroxatrine, displays very low affinity for alpha 1-adrenergic binding sites and a relatively high affinity for alpha 2-adrenergic binding sites. Nonetheless, recent functional studies indicate that spiroxatrine is a potent antagonist of the alpha 1-adrenoceptor mediating contraction
S K Sharma et al.
Neurochemical research, 19(6), 687-692 (1994-06-01)
Plasma concentration of prolactin was significantly reduced in pyridoxine-deficient as compared to control (pyridoxine-supplemented) adult male rats. Administration of pyridoxine to deficient rats resulted in a significant increase in plasma prolactin. The reduction in plasma prolactin in pyridoxine-deficient rats corresponded
J A Terrón et al.
Archives internationales de pharmacodynamie et de therapie, 327(1), 56-68 (1994-01-01)
This study aimed to investigate the mechanisms involved in the contractile effects produced by the novel quinoline derivative, 2-(2-aminoethyl)-quinoline (D-1997), in the canine isolated basilar artery. For comparison, the effects of D-1997 were also evaluated on rat aorta. Canine basilar
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