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R8907

Sigma-Aldrich

RPI-1

≥98% (HPLC)

Synonym(s):

1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-H-indol-2-one

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About This Item

Empirical Formula (Hill Notation):
C17H15NO4
CAS Number:
269730-03-2
Molecular Weight:
297.31
MDL number:
MFCD03852474
UNSPSC Code:
12352200
PubChem Substance ID:
329824042

assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >20 mg/mL

Storage temp.

2-8°C

SMILES string

COc1cc2NC(=O)C(=Cc3ccc(O)cc3)c2cc1OC

InChI

1S/C17H15NO4/c1-21-15-8-12-13(7-10-3-5-11(19)6-4-10)17(20)18-14(12)9-16(15)22-2/h3-9,19H,1-2H3,(H,18,20)

Inchi Key

JGSMCYNBVCGIHC-UHFFFAOYSA-N

Biochem/physiol Actions

RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Recently it was discover that the compound also inhibits c-Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus not surprisingly RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size (IC50 = 24.5 + 0.5 microM). Compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. It appears that " Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes ?-catenin transcriptional activity to drive thyrocyte neoplastic transformation". It appears that we do not have anything specific in Ret area. Handbook lists RPI-1 as Ret inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
089K4607

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Mrutyunjaya Parida et al.
mBio, 10(1) (2019-02-14)
The large genome of human cytomegalovirus (HCMV) is transcribed by RNA polymerase II (Pol II). However, it is not known how closely this betaherpesvirus follows host transcriptional paradigms. We applied PRO-Seq and PRO-Cap methods to profile and quantify transcription initiation
Vanessa D'Antongiovanni et al.
Cells, 9(5) (2020-05-24)
The role played by adenosine A2B receptors (A2BRs) in the regulation of enteric glial cell (EGC) functions remains unclear. This study was aimed at investigating the involvement of A2BRs in the control of EGC functions in a model of obesity.
Hyun-Jung Park et al.
Molecular endocrinology (Baltimore, Md.), 29(2), 289-306 (2014-12-31)
Glial cell line-derived neurotrophic factor (GDNF) is a TGFβ family member, and GDNF signals through a glycosyl-phosphatidylinositol-linked cell surface receptor (GFRα1) and RET receptor tyrosine kinase. GDNF signaling plays crucial roles in urogenital processes, ranging from cell fate decisions in
Lyle J Burdine et al.
PloS one, 10(6), e0127943-e0127943 (2015-06-13)
Constitutive activation of the Rearranged during Transfection (RET) proto-oncogene leads to the development of MEN2A medullary thyroid cancer (MTC). The relatively clear genotype/phenotype relationship seen with RET mutations and the development of MEN2A is unusual in the fact that a

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