R4282

RF9 trifluoroacetate salt

≥97% (HPLC)

• Synonym(s): 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
• Empirical Formula (Hill Notation): C₂₆H₃₈N₆O₃ · xC₂HF₃O₂
• CAS Number: 876310-60-0
• Molecular Weight: 482.62 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824030
• NACRES: NA.77

Properties

• assay: ≥97% (HPLC)
• solubility: H₂O: 20 mg/mL
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1
• InChI key: GPVFYPYIOXHDCU-CFIUKZCSSA-N

Description

Biochem/physiol Actions

RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)