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R2533

Sigma-Aldrich

RS-127445 hydrochloride

≥98% (HPLC), powder

Synonym(s):

2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H16FN3 · HCl
CAS Number:
199864-86-3
Molecular Weight:
317.79
MDL number:
MFCD11112196
UNSPSC Code:
12352200
PubChem Substance ID:
329824019
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥20 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23

InChI

1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H

InChI key

MKJPYBJBPRFMHL-UHFFFAOYSA-N

Biochem/physiol Actions

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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