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R2153

Sigma-Aldrich

RU 26752

≥98% (HPLC), solid

Synonym(s):

17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone

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About This Item

Empirical Formula (Hill Notation):
C25H36O3
CAS Number:
76676-33-0
Molecular Weight:
384.55
MDL number:
MFCD06201853
UNSPSC Code:
51111800
PubChem Substance ID:
329824013
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 20 mg/mL at 60 °C (warming up for 20 minutes)

Storage temp.

−20°C

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]34CCC(=O)O4)[C@]1([H])[C@H](CCC)CC5=CC(=O)CC[C@]25C

InChI

1S/C25H36O3/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24)13-9-21(27)28-25/h15-16,19-20,22H,4-14H2,1-3H3/t16-,19+,20+,22-,23+,24+,25-/m1/s1

Inchi Key

MOFIIHQCTIJVBB-JEHIOXJOSA-N

Biochem/physiol Actions

Mineralocorticoid receptor antagonist.
RU 26752 is a mineralocorticoid receptor antagonist.

Pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
026K46264
026K46263
026K46262
026K46261
026K4626

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L A Rollins-Smith et al.
Developmental immunology, 5(2), 145-152 (1997-01-01)
In recent years, integrative animal biologists and behavioral scientists have begun to understand the complex interactions between the immune system and the neuroendocrine system. Amphibian metamorphosis offers a unique opportunity to study dramatic hormone-driven changes in the immune system in
M Kalimi et al.
The American journal of physiology, 258(5 Pt 1), E737-E739 (1990-05-01)
The effect of mineralocorticoid antagonist RU 26752 on the development and maintenance of hypertension produced by long-term administration of mineralocorticoid agonist aldosterone has been investigated. Uninephrectomized, saline-drinking male Sprague-Dawley rats were subcutaneously implanted with either placebo (control) pellets or pellets
W G Luttge et al.
Endocrinology, 125(3), 1194-1203 (1989-09-01)
It is often implied that the various molecular, physiological, and behavioral responses to the glucocorticoid dexamethasone (DEX) are mediated in brain exclusively via the interactions of this synthetic steroid with the classical glucocorticoid (type II) receptor. The results reported in
M Mirshahi et al.
Biochemical and biophysical research communications, 270(3), 811-815 (2000-04-25)
PCR analysis and Western blotting revealed the expression of the mineralocorticoid receptor (MCR) and the epithelial sodium channel (ENaC) genes at the level of RNA, DNA, and protein in several leukemic cell lines, fibroblasts from human cornea, and epithelial cells
A Souque et al.
The Journal of steroid biochemistry and molecular biology, 57(5-6), 315-321 (1996-03-01)
To investigate the role of sulfhydryl groups in the interaction of agonists and antagonists with the human mineralocorticoid receptor (hMR) the effect of methyl methanethiosulfonate (MMTS) on free and liganded-hMR was examined. hMR was expressed in insect cells (Sf9) using
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