R107
Ro 41-1049 hydrochloride
solid
Synonym(s):
N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H12FN3OS · HCl
CAS Number:
Molecular Weight:
301.77
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
color
white
solubility
H2O: soluble
SMILES string
Cl[H].NCCNC(=O)c1ncsc1-c2cccc(F)c2
Gene Information
human ... MAOA(4128)
Biochem/physiol Actions
Selective, reversible, orally-active MAO-A inhibitor.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M J Heeringa et al.
Journal of neural transmission (Vienna, Austria : 1996), 104(6-7), 593-603 (1997-01-01)
The effect of enzyme-inhibiting adjuvants on L-DOPA + benserazide-induced contralateral turning in unilateral 6-hydroxydopamine (6-OHDA)-lesioned rats was studied. Both the number of turns and the duration of turning were examined. Inhibition of MAO-A with 10 mg/kg Ro 41-1049 increased both
M H Fernandes et al.
The Journal of pharmacology and experimental therapeutics, 255(3), 1309-1313 (1990-12-01)
The present study has examined the effects of two selective inhibitors of monoamine oxidase (MAO) type A and B, respectively Ro 41-1049 and Ro 19-6327, on the deamination of newly synthesized dopamine (DA) in kidney slices incubated with exogenous L-3,4-dihydroxyphenylalanine
J Saura et al.
Life sciences, 59(16), 1341-1349 (1996-01-01)
Localization of monoamine oxidases (MAO) A and B and beta-adrenoceptors, was studied in aged human peripheral tissues (age 68-80 years) by quantitative autoradiography. The tissues analyzed were heart, lung, liver, kidney, spleen and duodenum. [3H]Ro41-1049 and [3H]lazabemide, two recently characterized
J M Luque et al.
The Journal of comparative neurology, 363(4), 665-680 (1995-12-25)
Monoamine oxidases A and B (MAO-A and MAO-B) oxidatively deaminate neurotransmitter and xenobiotic amines. The cellular localization of these isoenzymes in the central nervous system (CNS) differs markedly and only partly reflects the distribution of their presumed natural substrates. In
A M Cesura et al.
Journal of neural transmission. Supplementum, 52, 189-200 (1998-06-13)
To gain insight into the structure of monoamine oxidases (MAO) A and B, we investigated the properties of various chimaeric enzymes, engineered by moving progressively the junction between the NH2- and the COOH-termini of each MAO form. Whereas exchange of
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