Q4972

QS11 hydrate

≥98% (HPLC), powder

• Synonym(s): (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
• Empirical Formula (Hill Notation): C₃₆H₃₃N₅O₂ · xH₂O
• CAS Number: 944328-88-5
• Molecular Weight: 567.68 (anhydrous basis)
• MDL number: MFCD12912439
• UNSPSC Code: 12352203

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL
• Storage temp.: 2-8°C
• SMILES string: O.OC[C@H](Cc1ccccc1)Nc2nc(Oc3ccc4CCCc4c3)nc5n(Cc6ccc(cc6)-c7ccccc7)cnc25

Description

Biochem/physiol Actions

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)