PZ0172

Gisadenafil besylate salt

≥98% (HPLC)

• Synonym(s): 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate besylate salt, UK 369003, UK 369003-26
• Empirical Formula (Hill Notation): C₂₃H₃₃N₇O₅S · C₆H₆O₃S
• CAS Number: 334827-98-4
• Molecular Weight: 677.79
• MDL number: MFCD18384964
• UNSPSC Code: 41106305
• PubChem Substance ID: 329823746
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >35 mg/mL
• storage temp.: 2-8°C
• SMILES string: OS(=O)(=O)c1ccccc1.CCOc2ncc(cc2C3=NC(=O)c4nn(CCOC)c(CC)c4N3)S(=O)(=O)N5CCN(CC)CC5
• InChI: 1S/C23H33N7O5S.C6H6O3S/c1-5-18-19-20(27-30(18)12-13-34-4)22(31)26-21(25-19)17-14-16(15-24-23(17)35-7-3)36(32,33)29-10-8-28(6-2)9-11-29;7-10(8,9)6-4-2-1-3-5-6/h14-15H,5-13H2,1-4H3,(H,25,26,31);1-5H,(H,7,8,9)
• InChI key: STFRDYSZKVPPQF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Gisadenafil (UK 369003) is a PDE5 inhibitor. It is 80 fold selective over PDE6, and greater than 3000 fold selective over PDEs 1-4 and 7.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable