P9887
Pro-Leu-Gly amide
≥97% (TLC)
Synonym(s):
MIF-I, Melanostatin, Oxytocin fragment 7-9
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About This Item
Empirical Formula (Hill Notation):
C13H24N4O3
CAS Number:
Molecular Weight:
284.35
EC Number:
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
assay
≥97% (TLC)
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)C1CCCN1)C(=O)NCC(N)=O
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M E Celis et al.
Proceedings of the National Academy of Sciences of the United States of America, 68(7), 1428-1433 (1971-07-01)
Microsomal preparations from the stalk median eminence of female rats are shown to contain an enzymic activity that is responsible for the formation of MSH-release-inhibiting factor (MSH-R-IF). The amount of this activity remains constant throughout the estrous cycle. The corresponding
Weihong Pan et al.
Peptides, 28(12), 2411-2434 (2007-11-09)
The Tyr-MIF-1 family of small peptides has served a prototypic role in the introduction of several novel concepts into the peptide field of research. MIF-1 (Pro-Leu-Gly-NH(2)) was the first hypothalamic peptide shown to act "up" on the brain, not just
Abigail Fisher et al.
Journal of medicinal chemistry, 49(1), 307-317 (2006-01-06)
Pro-Leu-Gly-NH(2) (PLG), in addition to its endocrine effects, possesses the ability to modulate dopamine D(2) receptors within the central nervous system. However, the precise binding site of PLG is unknown. Potential photoaffinity-labeling ligands of the PLG binding site were designed
Susan Rotzinger et al.
Peptides, 31(4), 736-756 (2009-12-23)
In recent years, studies have advocated neuropeptide systems as modulators for the behavioral states found in mood disorders such as depression and anxiety disorders. Neuropeptides have been tested in traditional animal models and screening procedures that have been validated by
Ashish P Vartak et al.
Journal of medicinal chemistry, 50(26), 6725-6729 (2007-12-07)
A peptidomimetic of Pro-Leu-Pro-NH2, 7, possessing an indolizidinone type VI beta-turn mimic was synthesized via improved high-yielding protocols for the preparation and Cbz protection of alpha-allylproline. Bicyclic peptidomimetic 7 and spirobicylic peptidomimetic 8 enhanced the binding of [3H] N-propylnorapomorphine to
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