P7674

Pyrantel (+)-tartrate salt

• Synonym(s): 1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine
• Empirical Formula (Hill Notation): C₁₁H₁₄N₂S · C₄H₆O₆
• CAS Number: 33401-94-4
• Molecular Weight: 356.39
• EC Number: 251-501-8
• MDL number: MFCD00216022
• UNSPSC Code: 51101500
• PubChem Substance ID: 329820314

Properties

• solubility: H₂O: 4.0 mL, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )
• antibiotic activity spectrum: parasites
• mode of action: enzyme | inhibits
• SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CCCN=C1\C=C\c2cccs2
• InChI: 1S/C11H14N2S.C4H6O6/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10;5-1(3(7)8)2(6)4(9)10/h2,4-6,9H,3,7-8H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/b6-5+;/t;1-,2-/m.1/s1
• InChI key: VWRCYAZJKNPEQR-NIEARKAZSA-N

Description

Application

Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).

Biochem/physiol Actions

Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. Cholinesterase inhibitor.

Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. This is a cholinesterase inhibitor. It causes spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges