P4543

Valproic acid sodium salt

98%

• Synonym(s): 2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate
• Empirical Formula (Hill Notation): C₈H₁₅NaO₂
• CAS Number: 1069-66-5
• Molecular Weight: 166.19
• EC Number: 213-961-8
• MDL number: MFCD00078604
• UNSPSC Code: 12352106
• eCl@ss: 42020819
• PubChem Substance ID: 24277744
• NACRES: NA.77

Properties

• assay: 98%
• form: powder
• solubility: H₂O: 50 mg/mL
• originator: Abbott
• SMILES string: [Na+].CCCC(CCC)C([O-])=O
• InChI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
• InChI key: AEQFSUDEHCCHBT-UHFFFAOYSA-M
• Gene Information: human ... ALDH5A1(7915)

Description

General description

The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions.



Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.

Application

Valproic acid sodium salt has been used:

• in resazurin viability assay
• to systematically study its effects of clinical doses on brain volume and offspring behavior
• to study its effect on atherosclerotic lesion size
• in genetic expression studies in mice

Biochem/physiol Actions

Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves