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P3998

Sigma-Aldrich

PGL-135 hydrochloride monohydrate

≥98% (HPLC), solid

Synonym(s):

2-Amino-4,7-dimethyl-6-hydroxybenzothiazole hydrochloride monohydrate

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5 MG
$78.47

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5 MG
$78.47

About This Item

Empirical Formula (Hill Notation):
C9H10N2OS · HCl · H2O
CAS Number:
Molecular Weight:
248.73
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

$78.47

List Price$82.60

In StockDetails


Request a Bulk Order

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

desiccated
protect from light
under inert gas

color

off-white

solubility

DMSO: >5 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].Cc1cc(O)c(C)c2sc(N)nc12

InChI

1S/C9H10N2OS.ClH/c1-4-3-6(12)5(2)8-7(4)11-9(10)13-8;/h3,12H,1-2H3,(H2,10,11);1H

InChI key

AIOZIUZKTGVUHB-UHFFFAOYSA-N

Biochem/physiol Actions

Cell-permeable polyglutamine aggregation inhibitor

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Volker Heiser et al.
Proceedings of the National Academy of Sciences of the United States of America, 99 Suppl 4, 16400-16406 (2002-08-30)
Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have potential clinical

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