P3905
pGlu-His-Pro
≥97% (TLC)
Synonym(s):
TRH, Thyrotropin releasing hormone
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About This Item
Empirical Formula (Hill Notation):
C16H21N5O5
CAS Number:
Molecular Weight:
363.37
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥97% (TLC)
storage temp.
−20°C
SMILES string
OC(=O)C1CCCN1C(=O)C(Cc2cnc[nH]2)NC(=O)C3CCC(=O)N3
Gene Information
mouse ... Trhr(22045)
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J López-Barneo et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(20), 8150-8154 (1990-10-01)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the patch-clamp technique. In about 60% of the cells tested, the
Concentrations of thyrotropin-releasing hormone (TRH) and deamido-TRH, and TRH deamidase activity in brain.
C H Emerson et al.
Endocrinology, 107(2), 443-449 (1980-08-01)
E C Griffiths et al.
Molecular and cellular endocrinology, 18(1), 59-67 (1980-04-01)
Specific radioimmunoassays for thyrotrophin-releasing hormone (TRH) and deamido-TRH (TRH-OH) were used to investigate the inactivation of TRH by subcellular fractions from rat hypothalamus. TRH-OH was rapidly formed from TRH by an amidase present only in the supernatant fraction at an
V Reny-Palasse et al.
Pain, 30(2), 259-269 (1987-08-01)
The antinociceptive action of the 2 main metabolites of thyrotropin-releasing hormone (TRH), pyroglutamyl-histidyl-proline (TRH-OH) and histidyl-proline-diketopiperazine or cyclo(His-Pro), were studied using mechanical (Haffner's test) and chemical (phenyl-p-benzoquinone writhing test) stimuli. TRH has previously been shown to be active against both
L Ouafik et al.
Annales d'endocrinologie, 47(1), 43-44 (1986-01-01)
This study allows the indirect demonstration of a precursor for TRH in pancreatic extracts of 2-days old rats. The sequential treatment of these extracts with trypsin and carboxypeptidase A is followed by a large increase in Pyroglutamyl Histidine Proline (TRH-OH).
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