P2149
Physalaemin
≥97% (HPLC)
Synonym(s):
pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C58H84N14O16S
CAS Number:
Molecular Weight:
1265.44
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C4CCC(=O)N4)C(N)=O
Gene Information
human ... INS(3630)
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Biochem/physiol Actions
Potent hypotensive; induces salivation, intestinal contraction and vasodilation
Other Notes
Tachykinin originally isolated from the skin of the amphibian, Physalaemus fuscumaculatus; with structural homology to substance P
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Takahiko Shiina et al.
European journal of pharmacology, 628(1-3), 202-206 (2009-12-05)
We examined the effects of physalaemin, an agonist of tachykinin receptors, on mechanical responses in the rat esophagus to clarify possible regulatory roles of tachykinins in esophageal motility. Exogenous application of physalaemin caused tonic contractions in rat esophageal segments when
Daniel A Nelson et al.
Frontiers in bioscience : a journal and virtual library, 9, 2166-2176 (2004-09-09)
Mammalian tachykinins are traditionally viewed as neuropeptides. This review describes the mammalian tachykinins and evidence for expression of these peptides by non-neuronal cells. Tachykinin expression is defined as evidence for gene transcription, peptide production, or peptide secretion. Since the functions
Pradeep K Singh et al.
Cell biochemistry and biophysics, 64(1), 29-44 (2012-05-26)
Protein aggregation and amyloid formation are associated with both pathological conditions in humans such as Alzheimer's disease and native functions such as peptide hormone storage in the pituitary secretory granules in mammals. Here, we studied amyloid fibrils formation by three
S Lobasso et al.
Archives of physiology and biochemistry, 105(4), 329-336 (1998-08-26)
The effects of the non-mammalian tachykinin physalaemin were studied on the short circuit current (SCC) and on both influx (Ji) and outflux (Jo) of 36Cl- and 22Na+ across the isolated skin of Rana esculenta. Physalaemin, added to the internal bathing
D Regoli et al.
Pharmacology, 38(1), 1-15 (1989-01-01)
The most widely used smooth muscle preparations for neurokinin bioassays have been critically analyzed in order to determine whether neurokinins act directly or by the intermediary of other natural agents. Indeed, part of the contraction of the GPI in response
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