P1641
5α-Pregnane-3β,11β,17α,21-tetrol-20-one
Synonym(s):
3β,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one, 3β,5α-Tetrahydrocortisol, 3β-Allotetrahydrocortisol, Reichstein’s substance V
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About This Item
Empirical Formula (Hill Notation):
C21H34O5
CAS Number:
Molecular Weight:
366.49
UNSPSC Code:
41116107
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J Müller-Berghaus et al.
Acta paediatrica (Oslo, Norway : 1992), 85(1), 111-113 (1996-01-01)
We report the case of a 16-month-old boy who presented with chronic vomiting, failure to thrive, arterial hypertension and medullary nephrocalcinosis. Laboratory results revealed hypokalaemia, metabolic alkalosis, increased urinary potassium excretion and a hyporeninaemic hypoaldosteronism. Chromatographic determination of urinary steroid
L M Muller et al.
Journal of steroid biochemistry, 31(6), 979-982 (1988-12-01)
The urinary levels of seven steroids, 5 alpha-androstane-3 alpha,17 beta-diol, 5 beta-androstane-3 alpha,17 beta-diol, androsterone, etiocholanolone, tetrahydrocortisone, tetrahydrocortisol and allotetrahydrocortisol were measured in both normal (n = 18) and hirsute (n = 24) women. The results confirmed 5 alpha-androstane-3 alpha,17
T A Mori et al.
Clinical and experimental pharmacology & physiology, 18(5), 287-290 (1991-05-01)
1. From an earlier cross-sectional survey of 343 public servants, 15 pairs of non-smoking teetotallers and heavy drinkers (alcohol intake more than 350 mL/week) were matched for age and adiposity and utilized for a case-control study of the effects of
P W Raven et al.
Endocrine research, 22(4), 811-815 (1996-11-01)
The increased ratio of 5 alpha to 5 beta reduced steroids associated with apparent mineralocorticoid excess (AME) may be a necessary consequence of altered 11 beta-hydroxysteroid dehydrogenase (11-HSD) activity. In order to test this hypothesis we have compared changes in
Franciszek K Główka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 283-289 (2009-12-19)
11Beta-hydroxysteroid dehydrogenase isoform 2 (11beta-HSD2) is responsible for conversion of cortisol (F) to inactive cortisone (E). Disturbance of its activity can cause hypertension. To estimate 11beta-HSD2 activity, besides F and E, their tetrahydro- (THF, THE) as well allo-tetrahydro- (allo-THF, allo-THE)
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