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P0391

Supelco

5α-Pregnane-3β,11β,21-triol-20-one

Synonym(s):

3β,11β,21-Trihydroxy-5α-pregnan-20-one, 3β,5α-Tetrahydrocorticosterone, 3β-Allotetrahydrocorticosterone, Allopregnane-3β,11β,21-triol-20-one, Reichstein’s substance R

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About This Item

Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
516-16-5
Molecular Weight:
350.49
UNSPSC Code:
41116107

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
076H4072
056H4020
026H4070

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A Soro et al.
Journal of human hypertension, 9(6), 391-393 (1995-06-01)
In a large group of patients with untreated hypertension, excretion rates of tetrahydrocorticosterone (THB), allotetrahydrocorticosterone (alloTHB) and tetrahydro-11-dehydrocorticosterone (THA) were all significantly higher than in a group of matched normotensive controls. Using the sum of these metabolites as an index
Y B Saalmann et al.
Journal of neuroendocrinology, 19(4), 272-284 (2007-03-16)
The 3alpha-hydroxy,5alpha-reduced pregnane steroids, allopregnanolone and allotetrahydrodeoxycorticosterone, are the most potent endogenous positive modulators of GABA(A) receptor-mediated inhibition. This study presents the first immunohistochemical examination of the cellular distribution of 3alpha-hydroxy,5alpha-reduced pregnane steroids across the brain. We found a widespread
R A Tigranian et al.
Endocrinologia experimentalis, 14(1), 3-7 (1980-03-01)
The urinary excretion of 17-hydroxycorticosteroids and the relations between the glucocorticoids in urine and their precursors as well as between 17-hydroxycorticoids and 17-hydroxycorticoids and 17-dehydroxycorticosteroids was measured in two subjects before and after 8 days flight in spaceship "Soyuz-22". During
Kendall D W Morris et al.
Molecular pharmacology, 66(1), 56-69 (2004-06-24)
Rho(1) receptor-channels (rho(1)Rs) are GABA-gated chloride channels that exhibit slow kinetics, little desensitization, and inert pharmacology to most anesthetics, except for neuroactive steroids (NSs). NSs differentially modulate rho(1)Rs dependent on the steric arrangement of the hydrogen atom at the fifth
L Trachsel et al.
The European journal of neuroscience, 8(2), 319-328 (1996-02-01)
Infrared light transmittance imaging was used in rat hypothalamic slices to record an intrinsic optical signal (IOS) of the cell ensemble in the suprachiasmatic nuclei (SCN), the locus of the endogenous circadian clock. Upon optic chiasm stimulation, a transient IOS
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