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P0105

Sigma-Aldrich

PM-20

≥96% (HPLC), solid

Synonym(s):

1-[1,1′-Biphenyl]-4-yl-3,4-bis[(2-hydroxyethyl)thio]-1H-Pyrrole-2,5-dione

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About This Item

Empirical Formula (Hill Notation):
C20H19NO4S2
CAS Number:
863886-38-8
Molecular Weight:
401.50
MDL number:
MFCD11045302
UNSPSC Code:
12352200

assay

≥96% (HPLC)

form

solid

color

yellow

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

OCCSC1=C(SCCO)C(=O)N(C1=O)c2ccc(cc2)-c3ccccc3

InChI

1S/C20H19NO4S2/c22-10-12-26-17-18(27-13-11-23)20(25)21(19(17)24)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,22-23H,10-13H2

InChI key

RFZCIUONZTUZER-UHFFFAOYSA-N

Biochem/physiol Actions

PM-20 is a Cdc25A phosphatase inhibitor.

Caution

air sensitive

pictograms

Environment
GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Joon-Khim Loh et al.
BMC cancer, 10, 268-268 (2010-06-10)
High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment. A case-control study was performed using 34 resected gliomas, which were
Siddhartha Kar et al.
Molecular cancer therapeutics, 5(6), 1511-1519 (2006-07-05)
We have synthesized several new phenyl maleimide compounds, which are potent growth inhibitors of several human tumor cell lines. Among these, PM-20 was the most potent with an IC50 of 700 nmol/L for Hep3B human hepatoma cell growth. Two other
Irina V Chikalovets et al.
Fish & shellfish immunology, 42(2), 503-507 (2014-12-09)
Lectins (carbohydrate-binding proteins) are well known to actively participate in the defense functions of vertebrates and invertebrates where they play an important role in the recognition of foreign particles. In this study, we investigated of in vitro antifungal activity of

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