P0024

PG-01

≥98% (HPLC)

• Synonym(s): 2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide, N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide
• Empirical Formula (Hill Notation): C₂₈H₂₉N₃O₂
• CAS Number: 853138-65-5
• Molecular Weight: 439.55
• MDL number: MFCD03449821
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819979

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: −20°C
• SMILES string: CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c4ccccc4)cc1
• InChI: 1S/C28H29N3O2/c1-19(2)20-13-15-23(16-14-20)30-28(33)27(21-9-5-4-6-10-21)31(3)26(32)17-22-18-29-25-12-8-7-11-24(22)25/h4-16,18-19,27,29H,17H2,1-3H3,(H,30,33)
• InChI key: PQAYCXMQTUEDRD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CFTR mutations are responsible for cystic fibrosis. The most common mutation is ΔF508, but many others exist. Drugs which can correct channel function of a broad range of CFTR mutants are most desirable for clinical development. PG-01 is a potentiator of ΔF508 (Ka 70 nM) as well as mutants G551D and G1349D (Ka 1100 and 40 nM, respectively). Its broad spectrum may make it more desirable than more mutant-specific CFTR correctors.

PG-01 is a potentiator of ΔF508 (Ka 70 nM) as well as mutants G551D and G1349D (Ka 1100 and 40 nM, respectively).

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H413
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable