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O5501

Sigma-Aldrich

Oxyphenonium bromide

Synonym(s):

2-([Cyclohexylhydroxyphenylacetyl]oxy)-N,N-diethyl-N-methylethanaminium bromide

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About This Item

Linear Formula:
C21H34NO3Br
CAS Number:
50-10-2
Molecular Weight:
428.40
EC Number:
200-010-7
MDL number:
MFCD00050259
UNSPSC Code:
12161900
PubChem Substance ID:
24898019

description

cationic

assay

>98% (TLC)

mol wt

428.40 g/mol

SMILES string

Br.CC[N](C)(CC)CCOC(=O)C(O)(C1CCCCC1)c2ccccc2

InChI

1S/C21H34NO3.BrH/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3;1H

InChI key

JKJFWDDPBNHJPV-UHFFFAOYSA-N

Application

Oxyphenonium bromide has been used in a study to assess masking mechanisms of bitter taste of drugs. It has also been used in a study to investigate stoichiometric and microenvironmental effects on hydrolysis of propantheline in cyclodextrin solutions.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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T P Berezina et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 91(8), 893-902 (2005-10-29)
In experiments on unanaesthetized rabbits, myoelectric activity (contractile activity index) of distal ileum, caecum, and proximal colon in two sites was studied under stress induced by fastening a rabbit to the table in supine position. The stress caused sharp decrease
N Funasaki et al.
Journal of pharmaceutical sciences, 90(6), 740-748 (2001-05-18)
The effects of alpha-, beta-, and gamma-cyclodextrins (CDs) on the basic hydrolysis of propantheline bromide (PB) and oxyphenonium bromide (OB) are analyzed in terms of the stoichiometry and microenvironments of their complexes. The rate constant of each species is evaluated
[Use of endoscopic drug block of the vagus nerve and cryotherapy in the treatment of peptic ulcer].
V A Grushko et al.
Klinichna khirurhiia, (8)(8), 12-13 (1996-01-01)
T Joseph et al.
Arzneimittel-Forschung, 47(7), 869-872 (1997-07-01)
The effect of a combination of 150 mg tinidazole (CAS 19387-91-8) and 1 mg oxyphenonium bromide (CAS 50-10-2), referred to as the combination, was examined in various animal species to assess its safety. In mice and rats, the combination in
N Ya Kovalenko et al.
Bulletin of experimental biology and medicine, 140(2), 177-180 (2005-11-12)
Experiments employing ultrasound technique showed that nonselective blockade of central muscarinic cholinoceptors with amizyl significantly increases the number and lifespan of rats highly resistant to acute massive blood loss. This pretreatment increased individual resistance of the circulatory system to posthemorrhagic
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