O0266

Obestatin mouse, rat

synthetic

• Empirical Formula (Hill Notation): C₁₁₄H₁₇₄N₃₄O₃₁
• CAS Number: 869705-22-6
• Molecular Weight: 2516.81
• MDL number: MFCD08458632
• UNSPSC Code: 51111800
• PubChem Substance ID: 329818834
• NACRES: NA.32

Properties

• biological source: synthetic
• assay: ≥97% (HPLC)
• form: lyophilized powder
• color: white
• solubility: deionized water: 0.5-1 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O
• InChI: 1S/C114H174N34O31/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-/m0/s1
• InChI key: OJSXICLEROKMBP-FFUDWAICSA-N
• Gene Information: mouse ... Ghrl(58991) ; rat ... Ghrl(59301)

Description

Amino Acid Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2

General description

Obestatin is a 23 amino acid bioactive peptide encoded by the ghrelin gene.

Application

Obestatin has been used to study its effect on serum glucose and enzymatic parameters in rats and used to investigate its effect on plasma acyl-ghrelin and body weight in wistar rat.

Biochem/physiol Actions

Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).

Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable