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Key Documents

N9627

Sigma-Aldrich

Nicotinic acid hydroxamate

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O2
CAS Number:
Molecular Weight:
138.12
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

form

solid

storage temp.

−20°C

SMILES string

ONC(=O)c1cccnc1

InChI

1S/C6H6N2O2/c9-6(8-10)5-2-1-3-7-4-5/h1-4,10H,(H,8,9)

InChI key

IYCHDNQCHLMLJZ-UHFFFAOYSA-N

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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K Harada et al.
Research communications in chemical pathology and pharmacology, 49(2), 309-312 (1985-08-01)
The effect of oral administrations of nicotinohydroxamic acid (NHA) and neomycin (NM) in ammonia and urea metabolism were investigated in the rat. NHA and NM lowered the blood ammonia level, and NHA increased urinary excretion of urea and depressed urease
K Sugihara et al.
Xenobiotica; the fate of foreign compounds in biological systems, 30(5), 457-467 (2000-06-30)
1. The hydroxamic acids N-hydroxyphenacetin and N-hydroxy-2-acetylaminofluorene were reduced to the corresponding amides, phenacetin and 2-acetylaminofluorene respectively by rabbit blood supplemented with both NAD(P)H and FAD. These reducing activities were found in erythrocytes but not in plasma, and were sensitive
R A Izydore et al.
Research communications in chemical pathology and pharmacology, 70(3), 307-321 (1990-12-01)
A series of benzo- and dibenzohydroxamic acids were shown to have potent hypolipidemic activity in mice and rats lowering both serum cholesterol and triglyceride levels at 20 mg/kg/day. Selected derivatives lowered tissue lipids, i.e. liver, small intestine and aorta, and
A controlled clinical trial of nicotinohydroxamic acid and neomycin in advanced chronic liver disease.
C Hirayama et al.
Digestion, 25(2), 115-123 (1982-01-01)

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