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N8756

Supelco

Neriifolin

≥95%

Synonym(s):

14-Hydroxy-5β-card-20(22)-enolide 3-(6-deoxy-3-O-methyl-α-L-glucopyranoside), 3-([6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxy)-14-hydroxy-5β-card-20(22)-enolide]

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About This Item

Empirical Formula (Hill Notation):
C30H46O8
CAS Number:
466-07-9
Molecular Weight:
534.68
EC Number:
207-372-5
MDL number:
MFCD00056524
UNSPSC Code:
41116107

assay

≥95%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC5(C)C(CCC45O)C6=CC(=O)OC6)C2)C1O

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
054H0061
048F0483
014H0874

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James K T Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(27), 10461-10466 (2006-06-24)
We report here the results of a chemical genetic screen using small molecules with known pharmacologies coupled with a cortical brain slice-based model for ischemic stroke. We identified a small-molecule compound not previously appreciated to have neuroprotective action in ischemic
Qian Zhao et al.
Fitoterapia, 82(5), 735-741 (2011-04-05)
The effects of neriifolin, a cardiac glycoside from Cerbera manghas L. on various end-points of oncologic relevance (cell growth, cell cycle regulation, and apoptosis in HepG2 cells) were investigated. Neriifolin reduced viability of HepG2 cells, induced S and G2/M phase
C Maillaud et al.
Toxicon : official journal of the International Society on Toxinology, 60(6), 1013-1017 (2012-07-25)
We wish to report the first curative use of digoxin-specific Fab antibody fragments in a coconut crab Birgus latro L. poisoning in New Caledonia. The female patient, aged sixty-three with a previous history of cardiovascular and metabolic dysfunctions, showed marked
C Maillaud et al.
Toxicon : official journal of the International Society on Toxinology, 55(1), 81-86 (2009-07-14)
We report a double lethal coconut crab Birgus latro L. poisoning in New Caledonia. Both patients died after showing gastro-intestinal symptoms, major bradycardia with marked low blood pressure, and finally asystolia. Both had significative hyperkaliemia, suggesting a digitaline-like substance intoxication.
[Studies on the pharmacokinetics of 3H-neriifolin in rats].
K C Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 21(8), 572-579 (1986-08-01)
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