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N8287

Sigma-Aldrich

NSC 625987

≥97% (HPLC)

Synonym(s):

1,4-Dimethoxy-9-thio(10H)-acridone

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About This Item

Empirical Formula (Hill Notation):
C15H13NO2S
CAS Number:
141992-47-4
Molecular Weight:
271.33
MDL number:
MFCD08276925
UNSPSC Code:
12352200
PubChem Substance ID:
24724558

assay

≥97% (HPLC)

solubility

DMSO: 14 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(OC)c2C(=S)c3ccccc3Nc12

InChI

1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)

InChI key

KFAKESMKRPNZTM-UHFFFAOYSA-N

Biochem/physiol Actions

NSC 625987 is a selective, potent Cdk4/cyclin D1 inhibitor.

Caution

Air-sensitive

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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A Kubo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 5(12), 4279-4286 (2000-01-13)
Loss of p16 functional activity leading to disruption of the p16/cyclin-dependent kinase (CDK) 4:cyclin D/retinoblastoma pathway is the most common event in human tumorigenesis, suggesting that compounds with CDK4 kinase inhibitory activity may be useful to regulate cancer cell growth.

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