N7904
NS 521 oxalate
solid
Synonym(s):
1-(1-Butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine oxalate, 1-(1-Butyl-piperidin-4-yl)-1,3-dihydro-benzimidazol-2-one-oxalate
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About This Item
Empirical Formula (Hill Notation):
C16H23N3O · C2H2O4
CAS Number:
Molecular Weight:
363.41
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
color
white
solubility
H2O: 10 mg/mL
SMILES string
OC(=O)C(O)=O.CCCCN1CCC(CC1)N2C(=O)Nc3ccccc23
Biochem/physiol Actions
Novel benzimidazolone neuroprotective agent.
Legal Information
Sold under license from NeuroSearch (US Patent #6, 180,649).
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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M Grønborg et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 348-353 (1999-06-25)
NS521 (1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine) belongs to a group of novel benzimidazolones, which exhibit neurotrophic-like activities. In vitro, NS521 rescued neuronal PC12 cells from death induced by serum and nerve growth factor deprivation. The survival effect of NS521 appeared to reflect a delay
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