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N211

Sigma-Aldrich

NS 2028

solid

Synonym(s):

4H-8-Bromo-1,2,4-oxadiazolo[3,4-d]benz[b][1,4]oxazin-1-one

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About This Item

Empirical Formula (Hill Notation):
C9H5BrN2O3
CAS Number:
204326-43-2
Molecular Weight:
269.05
MDL number:
MFCD01530052
UNSPSC Code:
41106305
PubChem Substance ID:
24278068
NACRES:
NA.77

form

solid

color

white

solubility

DMSO: 13 mg/mL
ethanol: 4.8 mg/mL
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble

SMILES string

Brc1ccc2OCC3=NOC(=O)N3c2c1

InChI

1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2

InChI key

MUDRLQRJCGJJTB-UHFFFAOYSA-N

Gene Information

human ... GUCY1A2(2977) , GUCY1A3(2982) , GUCY1B2(2974) , GUCY1B3(2983)

Biochem/physiol Actions

Specific, soluble guanylyl cyclase inhibitor.

Legal Information

Sold under exclusive license from NeuroSearch A/S.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBN5750V
BCBN5750
BCBN3070
BCBN1535
051M1480V

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S P Olesen et al.
British journal of pharmacology, 123(2), 299-309 (1998-03-07)
1 The haeme-containing soluble guanylyl cyclase (alpha1beta1-heterodimer) is a major intracellular receptor and effector for nitric oxide (NO) and carbon monoxide (CO) and mediates many of their biological actions by increasing cyclic GMP. We have synthesized new oxadiazolo-benz-oxazins and have
Patricia Pablos et al.
Neuropharmacology, 99, 422-431 (2015-08-10)
Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concentration-dependently reduced subsequent

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