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N147

Sigma-Aldrich

[β-Ala8]-Neurokinin A Fragment 4-10

≥97% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):
C35H56N8O10S
CAS Number:
122063-01-8
Molecular Weight:
780.93
MDL number:
MFCD00143686
UNSPSC Code:
12352200
PubChem Substance ID:
329818580

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥60%

color

white

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C35H56N8O10S/c1-19(2)15-24(32(50)40-23(30(37)48)12-14-54-5)39-27(45)11-13-38-35(53)29(20(3)4)43-33(51)25(16-21-9-7-6-8-10-21)41-34(52)26(18-44)42-31(49)22(36)17-28(46)47/h6-10,19-20,22-26,29,44H,11-18,36H2,1-5H3,(H2,37,48)(H,38,53)(H,39,45)(H,40,50)(H,41,52)(H,42,49)(H,43,51)(H,46,47)/t22-,23-,24-,25-,26-,29-/m0/s1

InChI key

CKNPSJOMUQBPLA-WTWMNNMUSA-N

Gene Information

human ... TAC1(6863)

Amino Acid Sequence

Asp-Ser-Phe-Val-β-Ala-Leu-Met-NH2

Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor agonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
020M1424
069K1402
127K1177
037K1155
065K1139

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L Lavagno et al.
Neuropeptides, 35(2), 92-99 (2001-06-01)
Three types of tachykinin receptors, namely NK1, NK2 and NK3, are known to preferentially interact with substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), respectively. We previously demonstrated that NK1 and NK2 receptors are present on human monocytes
Cecilia Cialdai et al.
European journal of pharmacology, 549(1-3), 140-148 (2006-09-19)
The pharmacological profile of MEN15596 or (6-methyl-benzo[b]thiophene-2-carboxylic acid [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl)-cyclopentyl]-amide), a novel potent and selective tachykinin NK2 receptor antagonist endowed with oral activity, is described. At the human recombinant tachykinin NK2 receptor, MEN15596 showed subnanomolar affinity (pKi 10.1) and potently antagonized
Matthias Pawlak et al.
Neuroscience letters, 326(2), 113-116 (2002-06-12)
Using electrophysiological methods, we aimed in the present study to determine whether the NK(2) receptor is involved in the sensitization of articular afferents of the rat. Impulse activity from 27 single fine nerve fibres innervating knee joints was recorded during
Shu-ichi Kojima et al.
British journal of pharmacology, 162(5), 1179-1185 (2010-11-26)
Melatonin is involved in the regulation of colonic motility, and sensation, but little is known about the influence of melatonin on 5-hydroxytryptamine (5-HT) release from colonic mucosa. A tachykinin NK₂ receptor-selective agonist, [β-Ala⁸]-neurokinin A(4-10) [βAla-NKA-(4-10)] can induce 5-HT release from
Alicia S Smith et al.
Journal of gastroenterology and hepatology, 20(5), 697-704 (2005-04-28)
Inflammatory bowel disease (IBD) is associated with altered sensory and motor function in the human colon. The aim of the present study was to compare neuromuscular function in normal and IBD-affected colon in vitro, with emphasis on inhibitory enteric nerves
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