Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

N100

Sigma-Aldrich

Nalorphine hydrochloride

solid

Synonym(s):

N-Allylnormorphine HCl, Nalline HCl

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H21NO3 · HCl
CAS Number:
57-29-4
Molecular Weight:
347.84
EC Number:
200-321-8
MDL number:
MFCD00055164
UNSPSC Code:
12352200
PubChem Substance ID:
24897450

form

solid

drug control

USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

H2O: slightly soluble
dilute aqueous acid: soluble
ethanol: soluble

SMILES string

Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45

InChI

1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1

InChI key

NAHATSPWSULUAA-HWXFZQNOSA-N

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Mixed action opiate that is a partial agonist at μ and κ opioid receptors, and a low-affinity agonist at sigma receptors.

Caution

Photosensitive;

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

G Bot et al.
Journal of neurochemistry, 70(1), 358-365 (1998-01-09)
To investigate the role of Asp114 in the cloned rat mu-opioid receptor for ligand binding, the charged amino acid was mutated to an asparagine to generate the mutant mu receptor D114N. The wild-type mu receptor and the D114N mutant were
P J Emmerson et al.
The Journal of pharmacology and experimental therapeutics, 278(3), 1121-1127 (1996-09-01)
In C6 glioma cells stably expressing a homogeneous population of the cloned rat mu opioid receptor, the binding affinities of opioid agonists and subsequent activation of G protein were examined. Opioid receptor number in membranes of these cells was high
J M Musacchio
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 3(3), 191-200 (1990-06-01)
A critical review of the literature shows that the dysphoric and psychotomimetic side effects of sigma opiates reside in the levorotatory and not in the dextrorotatory or (+)-isomer, as currently believed. Nalorphine, levallorphan, (-)-pentazocine, (-)-3-hydroxy-N-propargylmorphinan, and MR 2034, all levorotatory
A E Remmers et al.
The Journal of pharmacology and experimental therapeutics, 288(2), 827-833 (1999-01-26)
A C6 glioma cell line stably transfected with the human kappa opioid receptor (kappaOR) was used to characterize receptor binding and G protein activation via the kappaOR by a comprehensive series of opioid ligands. The ligand-binding affinity for [3H]5alpha,7alpha, 8beta(-)-N-methyl-N-(7-Cl-pyrrolidinyl)-1-oxaspiro(4
C D King et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(2), 251-255 (1997-02-01)
Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these compounds, catalyzed by UDP-glucuronosyltransferases (UGTs), is well known to be a primary step in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service